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题名: Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations
作者: Hao, DaCheng;  Sun, Jie;  Furnes, Bjarte;  Schlenk, Daniel;  Li, MiaoXin;  Yang, ShengLi;  Yang, Ling
通讯作者: 杨凌
关键词: FMO3 ;  PCR-RFLP ;  polymorphism ;  allele frequency ;  genotype
刊名: CELL BIOCHEMISTRY AND FUNCTION
发表日期: 2007-07-01
DOI: 10.1027/cbf.1326
卷: 25, 期:4, 页:443-453
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Cell Biology
英文摘要: The aims of this study were to analyze flavin-containing monooxygenase 3 (FMO3) polymorphisms and allele and genotype frequencies in 256 Han Chinese and 50 African-American individuals, to compare the allele and genotype frequencies of these populations with those of other world populations. For Han Chinese, genotyping of three common single nucleotide polymorphisms, E158K, V257M and E308G was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). For African-Americans, genotyping of all coding exons was performed by modified PCR-single strand conformational polymorphism (SSCP). Evolutionary rates of FMO3 were estimated computationally. We found that there were significant differences in allele and genotype frequencies among Han Chinese, African-Americans and other world populations. In Han Chinese, the minor allele frequencies (MAFs) were 0.229 (E158K), 0.203 (V257M) and 0.148 (E308G), respectively. In African-Americans, MAFs were 0.48 (E158K), 0.05 (V257M) and 0.148 (E308G), respectively. There was rapid evolution during the divergence of primate FMO3. This is the first report comparing FMO alleles and genotypes between Han Chinese and African-Americans. A Han Chinese population database has been established for three gene polymorphisms. The data presented here justify further pharmacogenetic studies for potentially optimizing recommended drug dosages and evaluating relationships with disease processes. Copyright (C) 2006 John Wiley & Sons, Ltd.
关键词[WOS]: FLAVIN-CONTAINING MONOOXYGENASE ;  N-OXIDATION ;  IN-VIVO ;  HUMAN LIVER ;  METABOLISM ;  MUTATION ;  IDENTIFICATION ;  DISCOVERY ;  VARIANTS ;  LINKAGE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000248157500014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98669
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Dalian Med Univ, Dept Emergency Med, Dalian, Peoples R China
3.Univ Calif Riverside, Environm Toxicol Program, Riverside, CA 92521 USA
4.Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China
5.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
6.Chinese Acad Sci, Shanghai Res Ctr Biotechnol, Shanghai, Peoples R China

Recommended Citation:
Hao, DaCheng,Sun, Jie,Furnes, Bjarte,et al. Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations[J]. CELL BIOCHEMISTRY AND FUNCTION,2007,25(4):443-453.
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