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Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations
Hao, DaCheng; Sun, Jie; Furnes, Bjarte; Schlenk, Daniel; Li, MiaoXin; Yang, ShengLi; Yang, Ling; Yang L(杨凌); Yang L(杨凌)
关键词Fmo3 Pcr-rflp Polymorphism Allele Frequency Genotype
刊名CELL BIOCHEMISTRY AND FUNCTION
2007-07-01
DOI10.1027/cbf.1326
25期:4页:443-453
收录类别SCI
文章类型Article
部门归属18
项目归属1806
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]FLAVIN-CONTAINING MONOOXYGENASE ; N-OXIDATION ; IN-VIVO ; HUMAN LIVER ; METABOLISM ; MUTATION ; IDENTIFICATION ; DISCOVERY ; VARIANTS ; LINKAGE
英文摘要The aims of this study were to analyze flavin-containing monooxygenase 3 (FMO3) polymorphisms and allele and genotype frequencies in 256 Han Chinese and 50 African-American individuals, to compare the allele and genotype frequencies of these populations with those of other world populations. For Han Chinese, genotyping of three common single nucleotide polymorphisms, E158K, V257M and E308G was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). For African-Americans, genotyping of all coding exons was performed by modified PCR-single strand conformational polymorphism (SSCP). Evolutionary rates of FMO3 were estimated computationally. We found that there were significant differences in allele and genotype frequencies among Han Chinese, African-Americans and other world populations. In Han Chinese, the minor allele frequencies (MAFs) were 0.229 (E158K), 0.203 (V257M) and 0.148 (E308G), respectively. In African-Americans, MAFs were 0.48 (E158K), 0.05 (V257M) and 0.148 (E308G), respectively. There was rapid evolution during the divergence of primate FMO3. This is the first report comparing FMO alleles and genotypes between Han Chinese and African-Americans. A Han Chinese population database has been established for three gene polymorphisms. The data presented here justify further pharmacogenetic studies for potentially optimizing recommended drug dosages and evaluating relationships with disease processes. Copyright (C) 2006 John Wiley & Sons, Ltd.
语种英语
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WOS记录号WOS:000248157500014
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/98669
专题中国科学院大连化学物理研究所
通讯作者Yang L(杨凌); Yang L(杨凌)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Dalian Med Univ, Dept Emergency Med, Dalian, Peoples R China
3.Univ Calif Riverside, Environm Toxicol Program, Riverside, CA 92521 USA
4.Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China
5.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
6.Chinese Acad Sci, Shanghai Res Ctr Biotechnol, Shanghai, Peoples R China
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GB/T 7714
Hao, DaCheng,Sun, Jie,Furnes, Bjarte,et al. Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations[J]. CELL BIOCHEMISTRY AND FUNCTION,2007,25(4):443-453.
APA Hao, DaCheng.,Sun, Jie.,Furnes, Bjarte.,Schlenk, Daniel.,Li, MiaoXin.,...&杨凌.(2007).Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations.CELL BIOCHEMISTRY AND FUNCTION,25(4),443-453.
MLA Hao, DaCheng,et al."Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations".CELL BIOCHEMISTRY AND FUNCTION 25.4(2007):443-453.
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