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Preparation and evaluation of a vancomycin-immobilized silica monolith as chiral stationary phase for CEC
Dong, Xiaoli; Dong, Jing; Ou, Junjie; Zhu, Yan; Zou, Hanfa; Zou HF(邹汉法); Zou HF(邹汉法)
关键词Cec Enantioseparation Silica Monolith Vancomycin
刊名ELECTROPHORESIS
2007-08-01
ISSN0173-0835
DOI10.1002/elps.200600605
28期:15页:2606-2612
收录类别SCI
文章类型Article
部门归属18
项目归属1809
产权排名2;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]TUBULAR CAPILLARY ELECTROCHROMATOGRAPHY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; CHARGED POLYACRYLAMIDE-GELS ; ENANTIOMERIC SEPARATIONS ; MASS SPECTROMETRY ; COLUMN ; ENANTIOSEPARATION ; ELECTROPHORESIS ; DERIVATIVES ; RESOLUTION
英文摘要Enantiomeric separations in CEC with the macrocyclic antibiotic vancomycin immobilized silica monolith as a chiral stationary phase are presented. The monolithic silica capillary columns were prepared by a sol-gel process in fused-silica capillaries with an inner diameter of 50 mu m and subsequently in situ immobilization of vancomycin as a chiral selector by reductive amination. Enantioselectivity was obtained for eight pairs of enantiomers in nonaqueous polar organic or aqueous mobile phases and most of them were baseline-separated with high column efficiencies. it was observed that the organic modifier ratio (MeOH/ACN) in the polar organic mobile phase played a significant role in controlling the resolution and efficiency of the enantiomers. In enantiomeric separation of propranolol, repeatability for column efficiency and resolution in the nonaqueous mobile phase was given in terms of RSD values at 1.1 and 2.3% (n = 5) for run-to-run injections and 7.2 and 9.6% (n = 5) for column-to-column testing while repeatability for the separation of thalidomide in the aqueous mobile phase was given in terms of RSD values at 1.5, 2.8% and 6.1, 10.5%, respectively.
语种英语
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WOS记录号WOS:000248938400008
引用统计
被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/98673
专题中国科学院大连化学物理研究所
通讯作者Zou HF(邹汉法); Zou HF(邹汉法)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
2.Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
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GB/T 7714
Dong, Xiaoli,Dong, Jing,Ou, Junjie,et al. Preparation and evaluation of a vancomycin-immobilized silica monolith as chiral stationary phase for CEC[J]. ELECTROPHORESIS,2007,28(15):2606-2612.
APA Dong, Xiaoli.,Dong, Jing.,Ou, Junjie.,Zhu, Yan.,Zou, Hanfa.,...&邹汉法.(2007).Preparation and evaluation of a vancomycin-immobilized silica monolith as chiral stationary phase for CEC.ELECTROPHORESIS,28(15),2606-2612.
MLA Dong, Xiaoli,et al."Preparation and evaluation of a vancomycin-immobilized silica monolith as chiral stationary phase for CEC".ELECTROPHORESIS 28.15(2007):2606-2612.
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