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题名: Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Th1 cells within immune organ of mouse IgA nephropathy
作者: Jia, Lewen;  Wang, Chang;  Kong, Hongwei;  Yang, Jun;  Li, Fanglou;  Lv, Shen;  Xu, Guowang
通讯作者: 许国旺
关键词: IgA nephropathy ;  phospholipid ;  PA-MSHA vaccine ;  Th-2/Th-1 ;  high performance liquid chromatography ;  metabolic profiling
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2007-01-17
DOI: 10.1016/j.jpba.2006.07.040
卷: 43, 期:2, 页:646-654
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Phospholipids as a class of important constituents in the biomembranes have been paid increasing attention in many fields. IgA nephropathy is now generally known to be the most common form of primary glomerulonephritis in the world. However, phospholipids metabolism in IgA nephropathy was not clear. Until recently, there was no effective treatment available for patients with IgA nephropathy. In this paper, effect of PA-MSHA vaccine on plasma phospholipid metabolic profile of mouse IgA nephropathy was investigated using high performance liquid chromatography/mass spectrometry (HPLUMS) and principal components analysis (PCA). Female Balb/c mice were divided into four groups: model group, control group, PA-MSHA treatment group and medicine control group (dipyridamole + common threewingnut root). The experimental IgA nephropathy model was established by the immunity combination method of oral BSA and injection of SEB. It was found that combination of LC/MS technology with PCA can be successfully applied to phospholipids profile analysis, clearly classify the model group and normal group, and PA-MSHA treatment group is closer to the normal control group than medicine control group. The result showed that Th-2/Th-1 (=CD4+CD30+/CD4+CD30-) of the model group is 20.70 +/- 3.57, which is significantly higher than that of the control group (1.34 +/- 0.14) (P < 0.001). The Th-2/Th-1 ratio of the PA-MSHA treatment group and the medicine control group are lower than that of the model group (P < 0.01). It is suggested that mouse IgA nephropathy has the phospholipids metabolic abnormality, PA-MSHA vaccine cannot only regulate the abnormal phospholipids metabolism mouse with the IgA nephropathy, but also correct the over unbalance of Th-2/Th-1 proportion. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: TRAP MASS-SPECTROMETRY ;  HUMAN BLOOD ;  METABONOMICS ;  IDENTIFICATION ;  URINE ;  SPECTROSCOPY ;  RECOGNITION ;  SEVERITY ;  ACID ;  GENE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000243802700035
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98775
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, Dalian 116011, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 1, Expt Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Jia, Lewen,Wang, Chang,Kong, Hongwei,et al. Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Th1 cells within immune organ of mouse IgA nephropathy[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,43(2):646-654.
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