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题名: A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile
作者: Yuan, Kailong;  Kong, Hongwei;  Guan, Yufeng;  Yang, Jun;  Xu, Guowang
通讯作者: 许国旺
关键词: metabonomics ;  GC ;  organic acids ;  peak matching algorithm ;  type 2 diabetes ;  biomarkers
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2007-05-01
DOI: 10.1016/j.jchromb.2006.11.035
卷: 850, 期:1-2, 页:236-240
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: "Metabonomics" method requires the development of rapid, advanced analytical tools and GC will play an important role for its special advantage. In this study we shown the application of GC-based metabonomics to investigate the control and type 2 diabetes (DM2) patients by urinary organic acids metabolic profile. After peak matching, multivariate statistical analysis methods: principal components analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were used. The results showed that there was a relationship between organic acids metabolic profiles and DM2, and PLS-DA can distinguish the DM2 patients from the control. Five organic acids as potential biomarkers were identified. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  CAPILLARY-ELECTROPHORESIS ;  BIOLOGICAL-FLUIDS ;  SERUM ;  DIAGNOSIS ;  DISEASE ;  URINARY ;  CANCER
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000246703500030
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98781
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&D Ctr, Dalian 116023, Peoples R China
2.Dalian Med Univ, Dalian 116023, Peoples R China

Recommended Citation:
Yuan, Kailong,Kong, Hongwei,Guan, Yufeng,et al. A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,850(1-2):236-240.
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