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A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile
Yuan, Kailong; Kong, Hongwei; Guan, Yufeng; Yang, Jun; Xu, Guowang; Xu GW(许国旺); Xu GW(许国旺)
关键词Metabonomics Gc Organic Acids Peak Matching Algorithm Type 2 Diabetes Biomarkers
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2007-05-01
DOI10.1016/j.jchromb.2006.11.035
850期:1-2页:236-240
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; CAPILLARY-ELECTROPHORESIS ; BIOLOGICAL-FLUIDS ; SERUM ; DIAGNOSIS ; DISEASE ; URINARY ; CANCER
英文摘要"Metabonomics" method requires the development of rapid, advanced analytical tools and GC will play an important role for its special advantage. In this study we shown the application of GC-based metabonomics to investigate the control and type 2 diabetes (DM2) patients by urinary organic acids metabolic profile. After peak matching, multivariate statistical analysis methods: principal components analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were used. The results showed that there was a relationship between organic acids metabolic profiles and DM2, and PLS-DA can distinguish the DM2 patients from the control. Five organic acids as potential biomarkers were identified. (c) 2006 Elsevier B.V. All rights reserved.
语种英语
原文出处查看原文
WOS记录号WOS:000246703500030
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/98781
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺); Xu GW(许国旺)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&D Ctr, Dalian 116023, Peoples R China
2.Dalian Med Univ, Dalian 116023, Peoples R China
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Yuan, Kailong,Kong, Hongwei,Guan, Yufeng,et al. A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,850(1-2):236-240.
APA Yuan, Kailong.,Kong, Hongwei.,Guan, Yufeng.,Yang, Jun.,Xu, Guowang.,...&许国旺.(2007).A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,850(1-2),236-240.
MLA Yuan, Kailong,et al."A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 850.1-2(2007):236-240.
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