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A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile
Yuan, Kailong; Kong, Hongwei; Guan, Yufeng; Yang, Jun; Xu, Guowang; Xu GW(许国旺); Xu GW(许国旺)
KeywordMetabonomics Gc Organic Acids Peak Matching Algorithm Type 2 Diabetes Biomarkers
Source PublicationJOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2007-05-01
DOI10.1016/j.jchromb.2006.11.035
Volume850Issue:1-2Pages:236-240
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; CAPILLARY-ELECTROPHORESIS ; BIOLOGICAL-FLUIDS ; SERUM ; DIAGNOSIS ; DISEASE ; URINARY ; CANCER
Abstract"Metabonomics" method requires the development of rapid, advanced analytical tools and GC will play an important role for its special advantage. In this study we shown the application of GC-based metabonomics to investigate the control and type 2 diabetes (DM2) patients by urinary organic acids metabolic profile. After peak matching, multivariate statistical analysis methods: principal components analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were used. The results showed that there was a relationship between organic acids metabolic profiles and DM2, and PLS-DA can distinguish the DM2 patients from the control. Five organic acids as potential biomarkers were identified. (c) 2006 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000246703500030
Citation statistics
Cited Times:56[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/98781
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺); Xu GW(许国旺)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&D Ctr, Dalian 116023, Peoples R China
2.Dalian Med Univ, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Kailong,Kong, Hongwei,Guan, Yufeng,et al. A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,850(1-2):236-240.
APA Yuan, Kailong.,Kong, Hongwei.,Guan, Yufeng.,Yang, Jun.,Xu, Guowang.,...&许国旺.(2007).A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,850(1-2),236-240.
MLA Yuan, Kailong,et al."A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 850.1-2(2007):236-240.
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