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Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis
Gao, Peng; Shi, Chunyun; Tian, Jing; Shi, Xianzhe; Yuan, Kailong; Lu, Xin; Xu, Guowang; Xu GW(许国旺); Xu GW(许国旺)
KeywordCapillary Electrophoresis Tricarboxylic Acid Cycle Carboxylic Acids Antibiotic
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2007-05-09
DOI10.1016/j.jpba.2007.02.015
Volume44Issue:1Pages:180-187
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordMICROBIAL METABOLOMICS ; MASS-SPECTROMETRY ; RESISTANCE ; CHROMATOGRAPHY ; MECHANISMS ; SELECTION ; STRAINS ; TARGETS ; EFFLUX ; DRUGS
AbstractMetabolomics is a new branch of systems biology exerting its influence in many aspects. In order to appraise the effects of antibiotics on central carbon metabolism, a CE based method was set up. With this platform, we estimated the organic acid metabolite pools' fluctuation of Escherichia coli and Pseudomonas aeruginosa cultured under 11 different antibiotics' stimuli. Multivariate data analysis showed that different antibiotics had clustered distributions for each strain and could be easily distinguished. Genetic, metabolic and antibiotic mechanism differences could also be deduced by the aid of further correlation analysis. For P. aeruginosa, even synergy action amid antibiotics could be ascertained. (c) 2007 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000246350100025
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/98787
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺); Xu GW(许国旺)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Gao, Peng,Shi, Chunyun,Tian, Jing,et al. Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,44(1):180-187.
APA Gao, Peng.,Shi, Chunyun.,Tian, Jing.,Shi, Xianzhe.,Yuan, Kailong.,...&许国旺.(2007).Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,44(1),180-187.
MLA Gao, Peng,et al."Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 44.1(2007):180-187.
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