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题名: Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis
作者: Gao, Peng;  Shi, Chunyun;  Tian, Jing;  Shi, Xianzhe;  Yuan, Kailong;  Lu, Xin;  Xu, Guowang
通讯作者: 许国旺
关键词: capillary electrophoresis ;  tricarboxylic acid cycle ;  carboxylic acids ;  antibiotic
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2007-05-09
DOI: 10.1016/j.jpba.2007.02.015
卷: 44, 期:1, 页:180-187
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Metabolomics is a new branch of systems biology exerting its influence in many aspects. In order to appraise the effects of antibiotics on central carbon metabolism, a CE based method was set up. With this platform, we estimated the organic acid metabolite pools' fluctuation of Escherichia coli and Pseudomonas aeruginosa cultured under 11 different antibiotics' stimuli. Multivariate data analysis showed that different antibiotics had clustered distributions for each strain and could be easily distinguished. Genetic, metabolic and antibiotic mechanism differences could also be deduced by the aid of further correlation analysis. For P. aeruginosa, even synergy action amid antibiotics could be ascertained. (c) 2007 Elsevier B.V. All rights reserved.
关键词[WOS]: MICROBIAL METABOLOMICS ;  MASS-SPECTROMETRY ;  RESISTANCE ;  CHROMATOGRAPHY ;  MECHANISMS ;  SELECTION ;  STRAINS ;  TARGETS ;  EFFLUX ;  DRUGS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000246350100025
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98787
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Gao, Peng,Shi, Chunyun,Tian, Jing,et al. Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,44(1):180-187.
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