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Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis
Gao, Peng; Shi, Chunyun; Tian, Jing; Shi, Xianzhe; Yuan, Kailong; Lu, Xin; Xu, Guowang; Xu GW(许国旺); Xu GW(许国旺)
关键词Capillary Electrophoresis Tricarboxylic Acid Cycle Carboxylic Acids Antibiotic
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2007-05-09
DOI10.1016/j.jpba.2007.02.015
44期:1页:180-187
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]MICROBIAL METABOLOMICS ; MASS-SPECTROMETRY ; RESISTANCE ; CHROMATOGRAPHY ; MECHANISMS ; SELECTION ; STRAINS ; TARGETS ; EFFLUX ; DRUGS
英文摘要Metabolomics is a new branch of systems biology exerting its influence in many aspects. In order to appraise the effects of antibiotics on central carbon metabolism, a CE based method was set up. With this platform, we estimated the organic acid metabolite pools' fluctuation of Escherichia coli and Pseudomonas aeruginosa cultured under 11 different antibiotics' stimuli. Multivariate data analysis showed that different antibiotics had clustered distributions for each strain and could be easily distinguished. Genetic, metabolic and antibiotic mechanism differences could also be deduced by the aid of further correlation analysis. For P. aeruginosa, even synergy action amid antibiotics could be ascertained. (c) 2007 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000246350100025
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/98787
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺); Xu GW(许国旺)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
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GB/T 7714
Gao, Peng,Shi, Chunyun,Tian, Jing,et al. Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,44(1):180-187.
APA Gao, Peng.,Shi, Chunyun.,Tian, Jing.,Shi, Xianzhe.,Yuan, Kailong.,...&许国旺.(2007).Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,44(1),180-187.
MLA Gao, Peng,et al."Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 44.1(2007):180-187.
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