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题名: Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae
作者: Li, Qiurong;  Zhang, Qiang;  Wang, Meng;  Liu, Fuzhong;  Zhao, Sumin;  Ma, Jian;  Luo, Nan;  Li, Ning;  Li, Yousheng;  Xu, Guowang;  Li, Jieshou
通讯作者: 黎介寿
关键词: polyunsaturated fatty acids ;  caveolae ;  fatty acid composition ;  phospholipids ;  eNOS
刊名: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2007-10-15
DOI: 10.1016/j.abb.2007.06.023
卷: 466, 期:2, 页:250-259
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 2;5
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics
英文摘要: n - 3 Polyunsaturated fatty acids are assumed to play an important role in the prevention and treatment of atherosclerosis. Endothelial nitric-oxide synthase (eNOS) is responsible for cardiovascular homeostasis involving in regulation of vascular function, and the subcellular localization is critical for its activation. Here we determined the effect of docosahexaenoic acid (DHA, 22:6 n - 3) on distribution of eNOS and its activity. DHA treatment markedly altered lipid environment of caveolae microdomains, which was coincided with selective displacement of caveolin-1 and eNOS from caveolae. Akt was not detected in caveolae fractions and CaM was distributed in both of caveolin-1-enriched membranes and non-caveolar fractions, whose distribution was unaffected by DHA. These data demonstrated for the first time that DHA altered caveolae microenvironment not only by modifying membrane lipid composition, but also by changing distribution of major structural proteins. DHA-induced alterations in caveolae lipid/protein environment may be an important mechanism in the development of pathogenesis of atherosclerosis. (c) 2007 Elsevier Inc. All rights reserved.
关键词[WOS]: POLYUNSATURATED FATTY-ACIDS ;  PROTEIN-KINASE B ;  EICOSAPENTAENOIC ACID ;  SIGNAL-TRANSDUCTION ;  LIPID-COMPOSITION ;  MEMBRANE DOMAINS ;  BINDING DOMAIN ;  BLOOD-PRESSURE ;  ACTIVATION ;  LOCALIZATION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000250067700012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98813
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
3.Nanjing Univ, Sch Med, Nanjing 210093, Peoples R China

Recommended Citation:
Li, Qiurong,Zhang, Qiang,Wang, Meng,et al. Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,2007,466(2):250-259.
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