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Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae
Li, Qiurong; Zhang, Qiang; Wang, Meng; Liu, Fuzhong; Zhao, Sumin; Ma, Jian; Luo, Nan; Li, Ning; Li, Yousheng; Xu, Guowang; Li, Jieshou; Li JS(黎介寿); Li JS(黎介寿)
关键词Polyunsaturated Fatty Acids Caveolae Fatty Acid Composition Phospholipids Enos
刊名ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
2007-10-15
DOI10.1016/j.abb.2007.06.023
466期:2页:250-259
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名2;5
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]POLYUNSATURATED FATTY-ACIDS ; PROTEIN-KINASE B ; EICOSAPENTAENOIC ACID ; SIGNAL-TRANSDUCTION ; LIPID-COMPOSITION ; MEMBRANE DOMAINS ; BINDING DOMAIN ; BLOOD-PRESSURE ; ACTIVATION ; LOCALIZATION
英文摘要n - 3 Polyunsaturated fatty acids are assumed to play an important role in the prevention and treatment of atherosclerosis. Endothelial nitric-oxide synthase (eNOS) is responsible for cardiovascular homeostasis involving in regulation of vascular function, and the subcellular localization is critical for its activation. Here we determined the effect of docosahexaenoic acid (DHA, 22:6 n - 3) on distribution of eNOS and its activity. DHA treatment markedly altered lipid environment of caveolae microdomains, which was coincided with selective displacement of caveolin-1 and eNOS from caveolae. Akt was not detected in caveolae fractions and CaM was distributed in both of caveolin-1-enriched membranes and non-caveolar fractions, whose distribution was unaffected by DHA. These data demonstrated for the first time that DHA altered caveolae microenvironment not only by modifying membrane lipid composition, but also by changing distribution of major structural proteins. DHA-induced alterations in caveolae lipid/protein environment may be an important mechanism in the development of pathogenesis of atherosclerosis. (c) 2007 Elsevier Inc. All rights reserved.
语种英语
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WOS记录号WOS:000250067700012
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/98813
专题中国科学院大连化学物理研究所
通讯作者Li JS(黎介寿); Li JS(黎介寿)
作者单位1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
3.Nanjing Univ, Sch Med, Nanjing 210093, Peoples R China
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GB/T 7714
Li, Qiurong,Zhang, Qiang,Wang, Meng,et al. Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,2007,466(2):250-259.
APA Li, Qiurong.,Zhang, Qiang.,Wang, Meng.,Liu, Fuzhong.,Zhao, Sumin.,...&黎介寿.(2007).Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,466(2),250-259.
MLA Li, Qiurong,et al."Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae".ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 466.2(2007):250-259.
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