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Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae
Li, Qiurong; Zhang, Qiang; Wang, Meng; Liu, Fuzhong; Zhao, Sumin; Ma, Jian; Luo, Nan; Li, Ning; Li, Yousheng; Xu, Guowang; Li, Jieshou; Li JS(黎介寿); Li JS(黎介寿)
KeywordPolyunsaturated Fatty Acids Caveolae Fatty Acid Composition Phospholipids Enos
Source PublicationARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
2007-10-15
DOI10.1016/j.abb.2007.06.023
Volume466Issue:2Pages:250-259
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank2;5
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS KeywordPOLYUNSATURATED FATTY-ACIDS ; PROTEIN-KINASE B ; EICOSAPENTAENOIC ACID ; SIGNAL-TRANSDUCTION ; LIPID-COMPOSITION ; MEMBRANE DOMAINS ; BINDING DOMAIN ; BLOOD-PRESSURE ; ACTIVATION ; LOCALIZATION
Abstractn - 3 Polyunsaturated fatty acids are assumed to play an important role in the prevention and treatment of atherosclerosis. Endothelial nitric-oxide synthase (eNOS) is responsible for cardiovascular homeostasis involving in regulation of vascular function, and the subcellular localization is critical for its activation. Here we determined the effect of docosahexaenoic acid (DHA, 22:6 n - 3) on distribution of eNOS and its activity. DHA treatment markedly altered lipid environment of caveolae microdomains, which was coincided with selective displacement of caveolin-1 and eNOS from caveolae. Akt was not detected in caveolae fractions and CaM was distributed in both of caveolin-1-enriched membranes and non-caveolar fractions, whose distribution was unaffected by DHA. These data demonstrated for the first time that DHA altered caveolae microenvironment not only by modifying membrane lipid composition, but also by changing distribution of major structural proteins. DHA-induced alterations in caveolae lipid/protein environment may be an important mechanism in the development of pathogenesis of atherosclerosis. (c) 2007 Elsevier Inc. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000250067700012
Citation statistics
Cited Times:59[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/98813
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi JS(黎介寿); Li JS(黎介寿)
Affiliation1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
3.Nanjing Univ, Sch Med, Nanjing 210093, Peoples R China
Recommended Citation
GB/T 7714
Li, Qiurong,Zhang, Qiang,Wang, Meng,et al. Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,2007,466(2):250-259.
APA Li, Qiurong.,Zhang, Qiang.,Wang, Meng.,Liu, Fuzhong.,Zhao, Sumin.,...&黎介寿.(2007).Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,466(2),250-259.
MLA Li, Qiurong,et al."Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae".ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 466.2(2007):250-259.
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