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Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry
Zhou, Da-Yong; Chen, De-Liang; Xu, Qing; Xue, Xing-Ya; Zhang, Fei-Fang; Liang, Xin-Miao; Liang XM(梁鑫淼); Liang XM(梁鑫淼)
KeywordLc-ms Cid Ms/ms Characterization Pmfs Fructus Aurantii
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2007-04-11
DOI10.1016/j.jpba.2006.12.032
Volume43Issue:5Pages:1692-1699
Indexed BySCI
SubtypeArticle
Department18
Funding Project1803
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordELECTROSPRAY-IONIZATION ; STRUCTURAL-CHARACTERIZATION ; CELL-LINES ; DISSOCIATION ; DIFFERENTIATION ; GLYCOSIDES ; IMMATURUS ; ISOMERS ; PEEL ; RATS
AbstractAtmospheric pressure chemical ionization mass spectrometry (APCI-MS) was operated in positive mode (PI) to characterize polymethoxylated flavonoids (PMFs) through its specific radical cations by collision-induced dissociation (CID). The fragments of [M + H - n x 15](+) produced by loss of one or more methyl group from the protonated molecule, as well as [M + H - 29](+), [M + H - 31](+), [M + H - 33](+), [M + H - 43](+), [M + H - 46](+), and [M + H - 61](+) fragment ions were detected, which were diagnostic for the polymethoxylated species, and could be adopted to form the multiple MS (MSn) "fingerprint" of PMFs. Based on this "fingerprint", 29 PMFs were screened out from extracts of Fructus aurantii, among which two of them were identified as sinensetin and tangeretin. It was proved that the PI was suitable for structural characterization of PMFs by APCI-MSn. (c) 2007 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000246008300014
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/98911
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiang XM(梁鑫淼); Liang XM(梁鑫淼)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Wuhan Univ, ZhongNan Hosp, Dept Internal Med, Div Cardiol, Wuhan 430071, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Da-Yong,Chen, De-Liang,Xu, Qing,et al. Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,43(5):1692-1699.
APA Zhou, Da-Yong.,Chen, De-Liang.,Xu, Qing.,Xue, Xing-Ya.,Zhang, Fei-Fang.,...&梁鑫淼.(2007).Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,43(5),1692-1699.
MLA Zhou, Da-Yong,et al."Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 43.5(2007):1692-1699.
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