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题名: Optimization of filtering criterion for SEQUEST database searching to improve proteome coverage in shotgun proteomics
作者: Jiang, Xinning;  Jiang, Xiaogang;  Han, Guanghui;  Ye, Mingliang;  Zou, Hanfa
通讯作者: 邹汉法
刊名: BMC BIOINFORMATICS
发表日期: 2007-08-31
DOI: 10.1186/1471-2105-8-323
卷: 8, 期:323, 页:40190
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods ;  Biotechnology & Applied Microbiology ;  Mathematical & Computational Biology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biotechnology & Applied Microbiology ;  Mathematical & Computational Biology
英文摘要: Background: In proteomic analysis, MS/MS spectra acquired by mass spectrometer are assigned to peptides by database searching algorithms such as SEQUEST. The assignations of peptides to MS/ MS spectra by SEQUEST searching algorithm are defined by several scores including Xcorr, Delta Cn, Sp, Rsp, matched ion count and so on. Filtering criterion using several above scores is used to isolate correct identifications from random assignments. However, the filtering criterion was not favorably optimized up to now.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  IDENTIFICATION TECHNOLOGY ;  LIQUID-CHROMATOGRAPHY ;  IDENTIFYING PROTEINS ;  STATISTICAL-MODEL ;  YEAST PROTEOME ;  SPECTRAL DATA ;  IN-VIVO ;  PEPTIDE ;  MS/MS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000250595500001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/99011
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Jiang, Xinning,Jiang, Xiaogang,Han, Guanghui,et al. Optimization of filtering criterion for SEQUEST database searching to improve proteome coverage in shotgun proteomics[J]. BMC BIOINFORMATICS,2007,8(323):40190.
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