DICP OpenIR
In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition
Zhang, Ying; Wang, Wei; Xie, Yubing; Yu, Weiting; Teng, Huaining; Liu, Xiudong; Zhang, Xulang; Guo, Xin; Fei, Jian; Ma, Xiaojun; Ma XJ(马小军); Ma XJ(马小军)
Source PublicationHUMAN GENE THERAPY
2007-05-01
DOI10.1089/hum.2006.166
Volume18Issue:5Pages:474-481
Indexed BySCI
SubtypeArticle
Department18
Funding Project1802
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
WOS Research AreaBiotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
WOS KeywordANGIOGENESIS ; THERAPY ; CANCER ; GROWTH
AbstractMicroencapsulation of recombinant cells is a novel alternative approach to tumor gene therapy. Therapeutic protein delivery can be sustained for systemic treatment of tumors because the recombinant cells are enclosed in microcapsules and the semipermeable membrane of the microcapsules protects the cells from host immune rejection and reduces the need for frequent injection. In this study, we describe a method to systemically inhibit tumor growth by in vivo culture of antiangiogenic endostatin-secreting Chinese hamster ovary (CHO) cells in microcapsules as small as 200 mu m in diameter. Peritoneal administration of encapsulated endostatin-CHO cells inhibited melanoma growth to 66.4% and enhanced the survival of treated mice to 80% by 27 days posttreatment. Continuous systemic release of endostatin from microcapsules offers an effective therapeutic strategy to eradicate solid tumors.
Language英语
URL查看原文
WOS IDWOS:000246904400008
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/99055
Collection中国科学院大连化学物理研究所
Corresponding AuthorMa XJ(马小军); Ma XJ(马小军)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ying,Wang, Wei,Xie, Yubing,et al. In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition[J]. HUMAN GENE THERAPY,2007,18(5):474-481.
APA Zhang, Ying.,Wang, Wei.,Xie, Yubing.,Yu, Weiting.,Teng, Huaining.,...&马小军.(2007).In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition.HUMAN GENE THERAPY,18(5),474-481.
MLA Zhang, Ying,et al."In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition".HUMAN GENE THERAPY 18.5(2007):474-481.
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