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In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition
Zhang, Ying; Wang, Wei; Xie, Yubing; Yu, Weiting; Teng, Huaining; Liu, Xiudong; Zhang, Xulang; Guo, Xin; Fei, Jian; Ma, Xiaojun; Ma XJ(马小军); Ma XJ(马小军)
刊名HUMAN GENE THERAPY
2007-05-01
DOI10.1089/hum.2006.166
18期:5页:474-481
收录类别SCI
文章类型Article
部门归属18
项目归属1802
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]ANGIOGENESIS ; THERAPY ; CANCER ; GROWTH
英文摘要Microencapsulation of recombinant cells is a novel alternative approach to tumor gene therapy. Therapeutic protein delivery can be sustained for systemic treatment of tumors because the recombinant cells are enclosed in microcapsules and the semipermeable membrane of the microcapsules protects the cells from host immune rejection and reduces the need for frequent injection. In this study, we describe a method to systemically inhibit tumor growth by in vivo culture of antiangiogenic endostatin-secreting Chinese hamster ovary (CHO) cells in microcapsules as small as 200 mu m in diameter. Peritoneal administration of encapsulated endostatin-CHO cells inhibited melanoma growth to 66.4% and enhanced the survival of treated mice to 80% by 27 days posttreatment. Continuous systemic release of endostatin from microcapsules offers an effective therapeutic strategy to eradicate solid tumors.
语种英语
原文出处查看原文
WOS记录号WOS:000246904400008
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/99055
专题中国科学院大连化学物理研究所
通讯作者Ma XJ(马小军); Ma XJ(马小军)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
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GB/T 7714
Zhang, Ying,Wang, Wei,Xie, Yubing,et al. In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition[J]. HUMAN GENE THERAPY,2007,18(5):474-481.
APA Zhang, Ying.,Wang, Wei.,Xie, Yubing.,Yu, Weiting.,Teng, Huaining.,...&马小军.(2007).In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition.HUMAN GENE THERAPY,18(5),474-481.
MLA Zhang, Ying,et al."In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition".HUMAN GENE THERAPY 18.5(2007):474-481.
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