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Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level
Gai, Hongwei2; Stayton, Isaac1; Liu, Xin3; Lin, Bingcheng3; Ma, Yinfa1; Yinfa Ma; Yinfa Ma
KeywordFluorescence Interaction Single-molecule Imaging Wide-field Microscopy
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
2007-11-01
DOI10.1016/j.trac.2007.09.007
Volume26Issue:10Pages:980-992
Indexed BySCI
SubtypeArticle
Department18
Funding Project1807
Contribution Rank3;1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordINTERNAL-REFLECTION FLUORESCENCE ; CAPILLARY-ZONE-ELECTROPHORESIS ; RESONANCE ENERGY-TRANSFER ; REAL-TIME ; LIVING CELLS ; PROTEIN INTERACTIONS ; RNA-POLYMERASE ; DNA-MOLECULES ; RADIAL MIGRATION ; PLANAR ZONE
AbstractSystematic understanding of dynamic biological networks is grounded at the molecular level. Knowledge at this level will discover the functions of molecular components and their interactions with cells or among the molecules themselves. Single-molecule detection has proved to be an indispensable technique for characterizing molecular interactions in various physiological conditions. Among the single-molecule-detection methods, wide-field microscopy-based fluorescence imaging is unique in that dynamic single-molecule events can be vividly observed in a wide observation field. Such a technique has obvious advantages for direct tracking of the pathways and processes of molecular interactions and giving visual information about the molecular mechanisms of many biological events. We discuss experimental schemes and applications of wide-field fluorescence microscopy in characterizing biological molecular interactions and studying virus-cell or particle-cell interactions. (C) 2007 Elsevier Ltd. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000251696700010
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/99499
Collection中国科学院大连化学物理研究所
Corresponding AuthorYinfa Ma; Yinfa Ma
Affiliation1.Univ Missouri, Dept Chem, Rolla, MO 65409 USA
2.Hunan Univ, Ctr Biomed Engn, Changsha 410082, Hunan, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 160023, Peoples R China
Recommended Citation
GB/T 7714
Gai, Hongwei,Stayton, Isaac,Liu, Xin,et al. Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2007,26(10):980-992.
APA Gai, Hongwei.,Stayton, Isaac.,Liu, Xin.,Lin, Bingcheng.,Ma, Yinfa.,...&Yinfa Ma.(2007).Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,26(10),980-992.
MLA Gai, Hongwei,et al."Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 26.10(2007):980-992.
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