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Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level
Gai, Hongwei2; Stayton, Isaac1; Liu, Xin3; Lin, Bingcheng3; Ma, Yinfa1; Yinfa Ma; Yinfa Ma
关键词Fluorescence Interaction Single-molecule Imaging Wide-field Microscopy
刊名TRAC-TRENDS IN ANALYTICAL CHEMISTRY
2007-11-01
DOI10.1016/j.trac.2007.09.007
26期:10页:980-992
收录类别SCI
文章类型Article
部门归属18
项目归属1807
产权排名3;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]INTERNAL-REFLECTION FLUORESCENCE ; CAPILLARY-ZONE-ELECTROPHORESIS ; RESONANCE ENERGY-TRANSFER ; REAL-TIME ; LIVING CELLS ; PROTEIN INTERACTIONS ; RNA-POLYMERASE ; DNA-MOLECULES ; RADIAL MIGRATION ; PLANAR ZONE
英文摘要Systematic understanding of dynamic biological networks is grounded at the molecular level. Knowledge at this level will discover the functions of molecular components and their interactions with cells or among the molecules themselves. Single-molecule detection has proved to be an indispensable technique for characterizing molecular interactions in various physiological conditions. Among the single-molecule-detection methods, wide-field microscopy-based fluorescence imaging is unique in that dynamic single-molecule events can be vividly observed in a wide observation field. Such a technique has obvious advantages for direct tracking of the pathways and processes of molecular interactions and giving visual information about the molecular mechanisms of many biological events. We discuss experimental schemes and applications of wide-field fluorescence microscopy in characterizing biological molecular interactions and studying virus-cell or particle-cell interactions. (C) 2007 Elsevier Ltd. All rights reserved.
语种英语
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WOS记录号WOS:000251696700010
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/99499
专题中国科学院大连化学物理研究所
通讯作者Yinfa Ma; Yinfa Ma
作者单位1.Univ Missouri, Dept Chem, Rolla, MO 65409 USA
2.Hunan Univ, Ctr Biomed Engn, Changsha 410082, Hunan, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 160023, Peoples R China
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Gai, Hongwei,Stayton, Isaac,Liu, Xin,et al. Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2007,26(10):980-992.
APA Gai, Hongwei.,Stayton, Isaac.,Liu, Xin.,Lin, Bingcheng.,Ma, Yinfa.,...&Yinfa Ma.(2007).Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,26(10),980-992.
MLA Gai, Hongwei,et al."Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 26.10(2007):980-992.
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