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题名: Inhibition of human liver cytochrome P450 by star fruit juice
作者: Zhang, Jiang-Wei1, 2;  Liu, Yong1;  Cheng, Jie1, 2;  Li, Wei1, 2;  Ma, Hong1;  Liu, Hong-Tao1, 2;  Sun, Jie3;  Wang, Li-Ming3;  He, Yu-Qi4;  Wang, Yun4;  Wang, Zheng-Tao4;  Yang, Ling1
通讯作者: 杨凌
刊名: JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
发表日期: 2007
卷: 10, 期:4, 页:496-503
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Purpose. To examine the inhibitory fruit (Averrhoa carambola) juice towards seven major cytochrome P450 (CYP) isoforms and NADPH-cytochrome P450 reductase (CPR). Methods. The inhibitory effects of star fruit juice (0.5 to 5%, v/v) against the activities of seven CYP isoforms including CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4 and CPR were examined in human liver microsomes. To identify time-dependent inhibition, star fruit juice (2.5%, v/v) was preincubated with microsomes and a NADPH-generating system for 0-15 min, and then the extent of inhibition towards seven CYP isoforms were examined. Results. Star fruit juice (5.0%, v/v) was found to inhibit all the activities of CYP isoforms tested by more than 70%. Based on the half inhibition values (%, v/v), the inhibitory effects towards different CYP isoforms were in the following order: CYP2A6 (0.9) > CYP1A2 (1.4) > CYP2D6 (1.6) > CYP2E1 (2.0) > CYP2C8 (2.2) > CYP2C9 (3.0) > CYP3A4 (3.2). Time-dependent inhibition was not observed towards any of the tested CYP isoforms. In addition, star fruit juice was found not to inhibit the activity of CPR. Conclusions. Star fruit juice inhibited the seven CYP isoforms tested, with the strongest inhibitory effect against CYP2A6 and the least towards CYP3A4.
关键词[WOS]: 3A CYP3A ACTIVITY ;  FEMALE A/J MICE ;  AVERRHOA-CARAMBOLA ;  LUNG TUMORIGENESIS ;  VALPROIC ACID ;  IN-VITRO ;  INTOXICATION ;  ENZYMES ;  RATS ;  8-METHOXYPSORALEN
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000253938600009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/99507
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 2, Dalian, Peoples R China
4.Univ Tradit Chinese Med, Shanghai, Peoples R China

Recommended Citation:
Zhang, Jiang-Wei,Liu, Yong,Cheng, Jie,et al. Inhibition of human liver cytochrome P450 by star fruit juice[J]. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES,2007,10(4):496-503.
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