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题名: An efficient resolution of racemic secondary alcohols on magnetically separable biocatalyst
作者: Zhang, Yanmei1;  Li, Jun1;  Han, Difei1;  Zhang, Huidong1;  Liu, Peng1;  Li, Can1
通讯作者: 李灿
关键词: magnetic nanoparticles ;  siliceous mesocellular foam ;  octyl groups ;  hydrophobic surface ;  lipase ;  pseudomonas cepacia ;  hyper-activation ;  racemic alcohols ;  recycling
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2008-01-25
DOI: 10.1016/j.bbrc.2007.10.205
卷: 365, 期:4, 页:609-613
收录类别: SCI
文章类型: Article
部门归属: 5
项目归属: 503
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics
英文摘要: The combination of magnetic nanoparticles and mesoporous silica can present a strategy for enzyme immobilization. In this work, magnetic siliceous mesocellular foam functionalized with octyl groups was prepared and used as support for lipase adsorption. Almost all the active lipases in crude enzyme solution were adsorbed by this magnetically separable, hydrophobic siliceous mesocellular foam. The resolution of 1-phenylethanol acylated with vinyl acetate can be achieved in 1.5 h using the resultant magnetic biocatalyst, whereas only 30% conversion was obtained by using the free lipase under the identical reaction conditions. These results are probably due to the "interfacial adsorption" and "hyper-activation" of lipase on the hydrophobic surface of the magnetic siliceous mesocellular foam. Moreover, the biocatalyst entrapped in the nanopores of this foam can be recycled magnetically for at least seven times without significant loss of its activity and enantioselectivity. (c) 2007 Elsevier Inc. All rights reserved.
关键词[WOS]: MESOCELLULAR MESOPOROUS SILICA ;  INTERFACIAL ADSORPTION ;  HYDROPHOBIC SUPPORTS ;  PSEUDOMONAS-CEPACIA ;  IMMOBILIZATION ;  NANOPARTICLES ;  ENZYMES ;  LIPASE ;  NANOCOMPOSITES ;  STABILIZATION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000251867100002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/99655
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Zhang, Yanmei,Li, Jun,Han, Difei,et al. An efficient resolution of racemic secondary alcohols on magnetically separable biocatalyst[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,365(4):609-613.
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