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题名: Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution
作者: Guo, Yong-Xue;  Xiu, Zhi-Long;  Zhang, Dai-Jia;  Wang, Hui;  Wang, Long-Xing;  Xiao, Hong-Bin
通讯作者: Zhi-long Xiu
关键词: lithospermic acid B ;  kinetics ;  reaction mechanism ;  hydrolysis ;  LC-MS
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2007-03-12
DOI: 10.1016/j.jpba.2006.10.025
卷: 43, 期:4, 页:1249-1255
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1804
产权排名: 2;5
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: The degradation of lithospermic acid B (LAB) was investigated as a function of buffer concentration, pH and temperature. Stability tests were performed using a stability-indicating high-performance liquid chromatography (HPLC) with UV-vis detection. The degradation followed pseudo-first-order kinetics under all experimental conditions. The maximum stability of LAB was observed at pH 2.0. The log k(pH)-pH profile described by specific acid-base catalysis and water molecules agreed with the experimental results. The overall degradation rate constant as a function of the temperature under the given conditions obeyed the Arrhenius equation. The chemical fate of LAB in mild acidic solution was investigated, and nine degradation products were detected and tentatively identified by LC-MS analysis. The primary degradation pathway involving the cleavage of ester bond and ring-opened of benzofuran in the LAB are proposed. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: SALVIA-MILTIORRHIZA ;  INHIBITION ;  RADIX ;  RATS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000245262300008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/99755
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Guo, Yong-Xue,Xiu, Zhi-Long,Zhang, Dai-Jia,et al. Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,43(4):1249-1255.
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