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题名: Studies of iridoid glycosides using liquid chromatography/electrospray ionization tandem mass spectrometry
作者: Ren, Lingling;  Xue, Xingya;  Zhang, Feifang;  Wang, Yongcan;  Liu, Yanfang;  Li, Cunman;  Liang, Xinmiao
通讯作者: 梁鑫淼
刊名: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
发表日期: 2007
DOI: 10.1002/rcm.3189
卷: 21, 期:18, 页:3039-3050
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Analytical ;  Spectroscopy
研究领域[WOS]: Chemistry ;  Spectroscopy
英文摘要: Fragmentation pathways of five iridoid glycosides have been studied by using electrospray ionization multi-stage tandem mass spectrometry (ESI-MSn). The first-stage MS data of the five iridoid glycosides were compared. The MS spectra showed that the adduct ions of iridoid glycosides and the formate anion were diagnostic ions to distinguish iridoid glycosides with a carboxyl group at the C-4 position or an ester group at the C-4 position. The MS fragmentation pathways of the five iridoid glycosides were also studied. Analyzing the product ion spectra of iridoid glycosides, some neutral losses were observed, such as H2O, CO2 and glucose residues, which were very useful for the identification of the functional groups in the structures of iridoid glycosides. Furthermore, specific loss of one molecule of methyl 3-oxopropanoate or 3-oxopropanic acid was firstly discussed, which corresponded to the isomerization of the hemiacetal group in the structure of iridoid aglycone. According to the fragmentation mechanisms and HPLC/MSn data, the structures of five iridoid glycosides in a crude extract of Gardenia jasminoisdes fruit have been identified. Three compounds were compared with standards and the other two were identified as shanzhiside and genipin gentibioside by their MSn data without standard compounds. In order to further validate the veracity of the deduction, genipin gentiobioside was isolated from the extract of Gardenia jasminoisdes fruit using Purification Factory and was further identified by C- and H-NMR. Copyright (c) 2007 John Wiley & Sons, Ltd.
关键词[WOS]: COLLISION-INDUCED DISSOCIATION ;  ELECTROKINETIC CAPILLARY CHROMATOGRAPHY ;  ELECTROSPRAY-IONIZATION ;  GARDENIA-JASMINOIDES ;  GENIPOSIDE ;  IDENTIFICATION ;  GLUCOSIDES ;  FRUIT ;  ACID
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000249457800016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/99807
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Ren, Lingling,Xue, Xingya,Zhang, Feifang,et al. Studies of iridoid glycosides using liquid chromatography/electrospray ionization tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2007,21(18):3039-3050.
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