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题名: Genome-wide analysis of coding DNA and amino acid variation in Saccharomyces cerevisiae
作者: Tan, Haidong1;  Wang, Jinxia1;  Yang, Fan1;  Zhao, Zongbao K.1
通讯作者: 谭海东
关键词: genome ;  coding DNA ;  base composition ;  amino acid composition ;  Saccharomyces cerevisiae
刊名: YEAST
发表日期: 2008
DOI: 10.1002/yea.1547
卷: 25, 期:1, 页:29-39
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1816
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Biotechnology & Applied Microbiology ;  Microbiology ;  Mycology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biotechnology & Applied Microbiology ;  Microbiology ;  Mycology
英文摘要: The possible causes of variation on amino acid composition in the yeast Saccharomyces cerevisiae were investigated genome-wide. The results indicated that: (a) the base composition of coding DNA and amino acid composition was similar among all the chromosomes, which was in sharp contrast with the great varies of the composition of the individual's coding DNA and amino acid; (b) some amino acids (e.g. Cys and Trp) were not present in all the proteins; and (c) amino acid bias was associated with a base bias (in terms of A-, G-, C- and T-rich codons). Based on the third rule and a proposed universal trend of amino acid gain and loss in protein evolution, the changing pattern of coding DNA was predicted to be T- and C-accruing, whereas A and G were consistently reducing. All these results held the potential to reveal precisely how DNA ongoing change has a major effect on the composition of proteins. Copyright (C) 2007 John Wiley & Sons, Ltd.
关键词[WOS]: NUCLEOTIDE BIAS ;  GENETIC-CODE ;  EVOLUTION ;  USAGE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000252869200004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/99897
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China

Recommended Citation:
Tan, Haidong,Wang, Jinxia,Yang, Fan,et al. Genome-wide analysis of coding DNA and amino acid variation in Saccharomyces cerevisiae[J]. YEAST,2008,25(1):29-39.
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