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题名: Recent development of monolithic stationary phases with emphasis on microscale chromatographic separation
作者: Wu, Ren'an1;  Hu, Lianghai1;  Wang, Fangjun1;  Ye, Mingliang1;  Zou, Hanfa1
通讯作者: 邹汉法
关键词: review ;  monoliths ;  column technology ;  chromatographic separation ;  stationary phases
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2008-03-14
DOI: 10.1016/j.chroma.2007.09.022
卷: 1184, 期:1-2, 页:369-392
收录类别: SCI
文章类型: Review
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The column technologies play a crucial role in the development of new methods and technologies for the separation of biological samples containing hundreds to thousands compounds. This review focuses on the development of monolithic technology in micro-column formats for biological analysis, especially in capillary liquid chromatography, capillary electrochromatography and microfluidic devices in the past 5 years (2002-2007) since our last review in 2002 on monoliths for HPLC and CEC [2]. The fabrication and functionalization of monoliths were summarized and discussed, with the aim of presenting how monolithic technology has been playing as an attractive tool for improving the power of existing chromatographic separation processes. This review consists of two parts: (i) the recent development in fabrication of monolithic stationary phases from direct synthesis to post-functionalization of the polymer- and silica-based monoliths tailoring the physical/chemical properties of porous monoliths; (ii) the application of monolithic stationary phases for one- and multi-dimensional capillary liquid chromatography, fast separation in capillary electro-driven chromatography, and microfluidic devices. (c) 2007 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  POROUS POLYMER MONOLITHS ;  SILICA CAPILLARY COLUMNS ;  OPENING METATHESIS POLYMERIZATION ;  IONIZATION MASS-SPECTROMETRY ;  PARTICLE-LOADED MONOLITHS ;  DANSYL AMINO-ACIDS ;  SOL-GEL PROCESS ;  COMPREHENSIVE 2-DIMENSIONAL HPLC ;  TRADITIONAL CHINESE MEDICINES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000254429600030
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/99913
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Wu, Ren'an,Hu, Lianghai,Wang, Fangjun,et al. Recent development of monolithic stationary phases with emphasis on microscale chromatographic separation[J]. JOURNAL OF CHROMATOGRAPHY A,2008,1184(1-2):369-392.
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