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Palladium-Catalyzed Propargylic [n+2] Cycloaddition: An Efficient Strategy for Construction of Benzo-Fused Medium-Sized Heterocycles 期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2019, 卷号: 361, 期号: 4, 页码: 836-841
Authors:  Liu, Zhen-Ting;  Hu, Xiang-Ping
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A regioselective palladium-catalyzed formal [n+2] cycloaddition of propargylic esters as C-2-synthons with various linker-tethered bisphenols for the construction of medium-sized heterocycles bearing an exocyclic double bond has been developed  The reaction features mild conditions and broad substrate scopes  as well as readily available substrates and catalysts  Under optimal conditions  various medium-sized heterocycles from eight to eleven-membered rings can be afforded in good to excellent yields and regioselectivities with high Z-selectivity for the exocyclic double bond  palladium  medium-sized ring  propargylic ester  bisphenol  cycloaddition