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Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu 期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
Authors:  Dai, Zi-Ru;  Ning, Jing;  Sun, Gui-Bo;  Wang, Ping;  Zhang, Feng;  Ma, Hong-Ping;  Zou, Li-Wei;  Hou, Jie;  Wu, Jing-Jing;  Ge, Guang-Bo;  Sun, Xiao-Bo;  Yang, Ling
Favorite  |  View/Download:10/0  |  Submit date:2019/06/20
bufotalin  cytochrome P450 3A (CYP3A)  hydroxylation  human liver microsomes (HLMs)  docking simulations  
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis 期刊论文
FITOTERAPIA, 2017, 卷号: 119, 页码: 26-31
Authors:  Zhao, Jin;  Sun, Tao;  Wu, Jing-Jing;  Cao, Yun-Feng;  Fang, Zhong-Ze;  Sun, Hong-Zhi;  Zhu, Zhi-Tu;  Yang, Kun;  Liu, Yong-Zhe;  Gonzalez, Frank J.;  Yin, Jun
Favorite  |  View/Download:57/0  |  Submit date:2017/10/29
Gomisin c  Gomisin g  Cyp3a4  Cyp3a5  Inhibition  Herb-drug Interactions  
A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 页码: 3804-3813
Authors:  Wu, Jing-Jing;  Cao, Yun-Feng;  Feng, Liang;  He, Yu-Qi;  Hong, James Y.;  Dou, Tong-Yi;  Wang, Ping;  Hao, Da-Cheng;  Ge, Guang-Bo;  Yang, Ling
Favorite  |  View/Download:47/0  |  Submit date:2017/10/29
一种细胞色素P4503A5的特异性抑制剂及其应用 专利
专利类型: 发明, 专利号: CN201410083732.1, 申请日期: 2015-11-01, 公开日期: 2015-09-09
Inventors:  杨凌;  葛广波;  宁静;  吴敬敬;  杜逊甫
Favorite  |  View/Download:62/0  |  Submit date:2015/11/16
Drug Metabolism and Pharmacokinetic Diversity of Ranunculaceae Medicinal 期刊论文
CURRENT DRUG METABOLISM, 2015, 卷号: 16, 期号: 1, 页码: 294
Authors:  Da-ChengHao;  Ge GB(葛广波);  Pei-GenXiao;  Wang P(王平);  Yang L(杨凌)
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Quantitative analysis of cytochrome P450 isoforms in human liver microsomes by the combination of proteomics and chemical probe-based assay 期刊论文
PROTEOMICS, 2014, 卷号: 14, 期号: 16, 页码: 1943-1951
Authors:  Liu, Xidong;  Hu, Lianghai;  Ge, Guangbo;  Yang, Bo;  Ning, Jing;  Sun, Shixin;  Yang, Ling;  Pors, Klaus;  Gu, Jingkai;  XidongLiu;  Ge GB(葛广波);  JingkaiGu
Adobe PDF(670Kb)  |  Favorite  |  View/Download:93/45  |  Submit date:2015/11/16
Biomedicine  Cytochrome P450  Mrm  Protein Quantification  Stable Isotope Labeling  
The differences in ligand structure between CYP3A4 and CYP3A5 (I): steroids 会议论文
, 天津, 41768
Authors:  Dai ZR(戴子茹);  Ge GB(葛广波);  Ning J(宁静);  Wu JJ(吴敬敬);  Yang L(杨凌)
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Deoxyschizandrin, a Naturally Occurring Lignan, Is a Specific Probe Substrate of Human Cytochrome P450 3A 期刊论文
DRUG METABOLISM AND DISPOSITION, 2014, 卷号: 42, 期号: 1, 页码: 94-104
Authors:  Wu, Jingjing;  Cao, Yunfeng;  Zhang, Yanyan;  Liu, Yong;  Hong, James Y.;  Zhu, Liangliang;  Ge, Guangbo;  Yang, Ling;  Yang L(杨凌)
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A highly selective probe for human cytochrome P450 3A4: isoform selectivity kinetic characterization and its applications 期刊论文
Chemical Communications, 2013, 卷号: 49, 页码: 9779
Authors:  Ge GB(葛广波);  Ning J(宁静);  Liang-Hai Hu;  Dai ZR(戴子茹);  Hou J(侯洁);  Cao YF(曹云峰);  Yu ZW(喻振文);  Ai CZ(艾纯芝);  Jing-Kai Gu;  Ma XC(马骁驰);  Yang L(杨凌)
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A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications 期刊论文
CHEMICAL COMMUNICATIONS, 2013, 卷号: 49, 期号: 84, 页码: 9779-9781
Authors:  Ge, Guang-Bo;  Ning, Jing;  Hu, Liang-Hai;  Dai, Zi-Ru;  Hou, Jie;  Cao, Yun-Feng;  Yu, Zhen-Wen;  Ai, Chun-Zhi;  Gu, Jing-Kai;  Ma, Xiao-Chi;  Yang, Ling
Favorite  |  View/Download:64/0  |  Submit date:2015/11/09