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Comprehensive Profiling by Non-targeted Stable Isotope Tracing Capillary Electrophoresis-Mass Spectrometry: A New Tool Complementing Metabolomic Analyses of Polar Metabolites 期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2019, 卷号: 25, 期号: 21, 页码: 5427-5432
Authors:  Zeng, Jun;  Wang, Zhichao;  Huang, Xin;  Eckstein, Sabine S.;  Lin, Xiaohui;  Piao, Hailong;  Weigert, Cora;  Yin, Peiyuan;  Lehmann, Rainer;  Xu, Guowang
Favorite  |  View/Download:4/0  |  Submit date:2019/06/20
capillary electrophoresis  isotopologues  mass spectrometry  metabolism  metabolomics  
Recent progress and challenges in screening and characterization of UGT1A1 inhibitors 期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 258-278
Authors:  Lv, Xia;  Xia, Yangliu;  Finel, Moshe;  Wu, Jingjing;  Ge, Guangbo;  Yang, Ling
Favorite  |  View/Download:3/0  |  Submit date:2019/06/20
UGT1A1 inhibitors  Drug/herbdrug interactions  Probe substrates  High-throughput screening  
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu 期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
Authors:  Dai, Zi-Ru;  Ning, Jing;  Sun, Gui-Bo;  Wang, Ping;  Zhang, Feng;  Ma, Hong-Ping;  Zou, Li-Wei;  Hou, Jie;  Wu, Jing-Jing;  Ge, Guang-Bo;  Sun, Xiao-Bo;  Yang, Ling
Favorite  |  View/Download:7/0  |  Submit date:2019/06/20
bufotalin  cytochrome P450 3A (CYP3A)  hydroxylation  human liver microsomes (HLMs)  docking simulations  
Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPK alpha 期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 卷号: 91, 页码: 18-29
Authors:  Yan, Min;  Qi, Huan;  Xia, Tian;  Zhao, Xinjie;  Wang, Wen;  Wang, Zhichao;  Lu, Chang;  Ning, Zhen;  Chen, Huan;  Li, Tongming;  Tekcham, Dinesh Singh;  Liu, Xiumei;  Liu, Jing;  Chen, Di;  Liu, Xiaolong;  Xu, Guowang;  Piao, Hai-long
Favorite  |  View/Download:6/0  |  Submit date:2019/07/26
Metformin  Ampk  Metabolomics  Metabolic flux  Independence  
N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice 期刊论文
JOURNAL OF DIABETES, 2019, 卷号: 11, 期号: 1, 页码: 32-45
Authors:  Zheng, Junping;  Yuan, Xubing;  Zhang, Chen;  Jia, Peiyuan;  Jiao, Siming;  Zhao, Xiaoming;  Yin, Heng;  Du, Yuguang;  Liu, Hongtao
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Akkermansia  gut microbiota  lipopolysaccharide  metabolic syndrome  N-acetylcysteine  
A Biomimetic Human Gut-on-a-Chip for Modeling Drug Metabolism in Intestine 期刊论文
ARTIFICIAL ORGANS, 2018, 卷号: 42, 期号: 12, 页码: 1196-1205
Authors:  Guo, Yaqiong;  Li, Zhongyu;  Su, Wentao;  Wang, Li;  Zhu, Yujuan;  Qin, Jianhua
Favorite  |  View/Download:5/0  |  Submit date:2019/06/20
Gut-on-a-chip  Caco-2  Intestinal metabolism  Biomimetic  Drug metabolism  
Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp 期刊论文
JOURNAL OF DIABETES, 2018, 卷号: 10, 期号: 11, 页码: 874-885
Authors:  Wang, Shujie;  Deng, Yuying;  Xie, Xiaoyan;  Ma, Jing;  Xu, Min;  Zhao, Xinjie;  Gu, Weiqiong;  Hong, Jie;  Wang, Weiqing;  Xu, Guowang;  Ning, Guang;  Gu, Yanyun;  Zhang, Yifei
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bile acid  hyperglycemic clamp  insulin secretion  type 2 diabetes mellitus  
Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2018, 卷号: 17, 期号: 4, 页码: 1575-1585
Authors:  Zhou, Yang;  Hu, Cheng;  Zhao, Xinjie;  Luo, Ping;  Lu, Jingyi;  Li, Qing;  Chen, Miao;  Yan, Dandan;  Lu, Xin;  Kong, Hongwei;  Jia, Weiping;  Xu, Guowang
Favorite  |  View/Download:9/0  |  Submit date:2019/06/20
Metabolomics  Gliclazide Modified Release  Sulfonylureas  Type 2 Diabetes Mellitus  Gas Chromatography-mass Spectrometry  Biomarker  
Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases 期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2018, 卷号: 284, 页码: 48-55
Authors:  Lv, Xia;  Zhang, Jian-Bin;  Wang, Xin-Xin;  Hu, Wen-Zhong;  Shi, Yu-Sheng;  Liu, Shu-Wen;  Hao, Da-Cheng;  Zhang, Wei-Dong;  Ge, Guang-Bo;  Hou, Jie;  Yang, Ling
Favorite  |  View/Download:8/0  |  Submit date:2019/06/20
Amentoflavone  Udp-glucuronosyltransferases  Broad-spectrum Inhibitor  Herb-drug Interactions (Hdis)  
Assessment of hepatic metabolism-dependent nephrotoxicity on an organs-on-a-chip microdevice 期刊论文
TOXICOLOGY IN VITRO, 2018, 卷号: 46, 页码: 1-8
Authors:  Li, Zhongyu;  Jiang, Lei;  Zhu, Yujuan;  Su, Wentao;  Xu, Cong;  Tao, Tingting;  Shi, Yang;  Qin, Jianhua
Favorite  |  View/Download:4/0  |  Submit date:2019/06/20
Microfluidics  Drug Testing  Hepatic Metabolism  Nephrotoxicity  Organs-on-a-chip