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Recent progress and challenges in screening and characterization of UGT1A1 inhibitors 期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 258-278
Authors:  Lv, Xia;  Xia, Yangliu;  Finel, Moshe;  Wu, Jingjing;  Ge, Guangbo;  Yang, Ling
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UGT1A1 inhibitors  Drug/herbdrug interactions  Probe substrates  High-throughput screening  
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu 期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
Authors:  Dai, Zi-Ru;  Ning, Jing;  Sun, Gui-Bo;  Wang, Ping;  Zhang, Feng;  Ma, Hong-Ping;  Zou, Li-Wei;  Hou, Jie;  Wu, Jing-Jing;  Ge, Guang-Bo;  Sun, Xiao-Bo;  Yang, Ling
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bufotalin  cytochrome P450 3A (CYP3A)  hydroxylation  human liver microsomes (HLMs)  docking simulations  
Simultaneous Quantification of Ten Oxysterols Based on LC-MS/MS and its Application in Atherosclerosis Human Serum Samples 期刊论文
CHROMATOGRAPHIA, 2019, 卷号: 82, 期号: 2, 页码: 553-564
Authors:  Chen, Lishan;  Xiu, Rui;  Wang, Huan;  Wang, Longxing;  Wu, Guanmin;  Liang, Jian;  Han, Xiaofei
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LC-MS  MS  Oxysterols  Human serum  Derivatization  Atherosclerosis  
In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system 期刊论文
LAB ON A CHIP, 2018, 卷号: 18, 期号: 23, 页码: 3606-3616
Authors:  Wang, Yaqing;  Wang, Hui;  Deng, Pengwei;  Chen, Wenwen;  Guo, Yaqiong;  Tao, Tingting;  Qin, Jianhua
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Short-chain chlorinated paraffins (SCCPs) induced thyroid disruption by enhancement of hepatic thyroid hormone influx and degradation in male Sprague Dawley rats 期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2018, 卷号: 625, 页码: 657-666
Authors:  Gong, Yufeng;  Zhang, Haijun;  Geng, Ningbo;  Xing, Liguo;  Fan, Jingfeng;  Luo, Yun;  Song, Xiaoyao;  Ren, Xiaoqian;  Wang, Feidi;  Chen, Jiping
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Short-chain Chlorinated Paraffins  Thyroid Disruption  Hepatic Metabolism  Thyroid Hormone  Constitutive Androstane Receptor  
Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography-High-Resolution Mass Spectrometry 期刊论文
ANALYTICAL CHEMISTRY, 2018, 卷号: 90, 期号: 9, 页码: 5712-5718
Authors:  Yu, Di;  Zhou, Lina;  Xuan, Qiuhui;  Wang, Lichao;  Zhao, Xinjie;  Lu, Xin;  Xu, Guowang
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Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2 期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 77, 页码: 320-329
Authors:  Weng, Zi-Miao;  Ge, Guang-Bo;  Dou, Tong-Yi;  Wang, Ping;  Liu, Ping-Kun;  Tian, Xin-Hui;  Qiao, Nan;  Yu, Yang;  Zou, Li-Wei;  Zhou, Qi;  Zhang, Wei-Dong;  Hou, Jie
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Flavonoids  Human Carboxylesterase 2 (Hce2)  Structure-inhibition Relationships  Selectivity  Inhibition Mechanism  
New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9 期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 卷号: 122, 期号: 4, 页码: 424-428
Authors:  Xiao, Ling;  Zhu, Liangliang;  Li, Wenjuan;  Li, Conghu;  Cao, Yunfeng;  Ge, Guangbo;  Sun, Xiaoyu
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Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases 期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2018, 卷号: 284, 页码: 48-55
Authors:  Lv, Xia;  Zhang, Jian-Bin;  Wang, Xin-Xin;  Hu, Wen-Zhong;  Shi, Yu-Sheng;  Liu, Shu-Wen;  Hao, Da-Cheng;  Zhang, Wei-Dong;  Ge, Guang-Bo;  Hou, Jie;  Yang, Ling
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Amentoflavone  Udp-glucuronosyltransferases  Broad-spectrum Inhibitor  Herb-drug Interactions (Hdis)  
A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs) 期刊论文
ENVIRONMENTAL POLLUTION, 2018, 卷号: 234, 页码: 572-580
Authors:  Wang, Feidi;  Zhang, Haijun;  Geng, Ningbo;  Ren, Xiaoqian;  Zhang, Baoqin;  Gong, Yufeng;  Chen, Jiping
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Combined Toxicity  Metabolomics  Polycyclic Aromatic Hydrocarbons  Short-chain Chlorinated Paraffins