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Short-chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor a (PPAR alpha) 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 181, 页码: 164-171
Authors:  Gong, Yufeng;  Zhang, Haijun;  Geng, Ningbo;  Ren, Xiaoqian;  Giesy, John P.;  Luo, Yun;  Xing, Liguo;  Wu, Ping;  Yu, Zhengkun;  Chen, Jiping
Favorite  |  View/Download:16/0  |  Submit date:2019/12/02
SCCPs  Mode of action  PPAR alpha  Luciferase assay  Molecular docking  Metabolomics  
Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints 期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2019, 卷号: 317, 期号: 2, 页码: E374-E387
Authors:  Kappler, Lisa;  Hoene, Miriam;  Hu, Chunxiu;  von Toerne, Christine;  Li, Jia;  Bleher, Daniel;  Hoffmann, Christoph;  Boehm, Anja;  Kollipara, Laxmikanth;  Zischka, Hans;  Koenigsrainer, Alfred;  Haering, Hans-Ulrich;  Peter, Andreas;  Xu, Guowang;  Sickmann, Albert;  Hauck, Stefanie M.;  Weigert, Cora;  Lehmann, Rainer
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cardiolipins  liver  mitochondria  multi-omics  muscle  
Advances in Hydrogels in Organoids and Organs-on-a-Chip 期刊论文
ADVANCED MATERIALS, 2019, 页码: 28
Authors:  Liu, Haitao;  Wang, Yaqing;  Cui, Kangli;  Guo, Yaqiong;  Zhang, Xu;  Qin, Jianhua
Favorite  |  View/Download:12/0  |  Submit date:2019/12/02
3D tissue models  hydrogels  organoids  organs-on-a-chip  stem cells  
Recent progress and challenges in screening and characterization of UGT1A1 inhibitors 期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 258-278
Authors:  Lv, Xia;  Xia, Yangliu;  Finel, Moshe;  Wu, Jingjing;  Ge, Guangbo;  Yang, Ling
Favorite  |  View/Download:11/0  |  Submit date:2019/06/20
UGT1A1 inhibitors  Drug/herbdrug interactions  Probe substrates  High-throughput screening  
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu 期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
Authors:  Dai, Zi-Ru;  Ning, Jing;  Sun, Gui-Bo;  Wang, Ping;  Zhang, Feng;  Ma, Hong-Ping;  Zou, Li-Wei;  Hou, Jie;  Wu, Jing-Jing;  Ge, Guang-Bo;  Sun, Xiao-Bo;  Yang, Ling
Favorite  |  View/Download:19/0  |  Submit date:2019/06/20
bufotalin  cytochrome P450 3A (CYP3A)  hydroxylation  human liver microsomes (HLMs)  docking simulations  
Simultaneous Quantification of Ten Oxysterols Based on LC-MS/MS and its Application in Atherosclerosis Human Serum Samples 期刊论文
CHROMATOGRAPHIA, 2019, 卷号: 82, 期号: 2, 页码: 553-564
Authors:  Chen, Lishan;  Xiu, Rui;  Wang, Huan;  Wang, Longxing;  Wu, Guanmin;  Liang, Jian;  Han, Xiaofei
Favorite  |  View/Download:16/0  |  Submit date:2019/06/20
LC-MS  MS  Oxysterols  Human serum  Derivatization  Atherosclerosis  
In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system 期刊论文
LAB ON A CHIP, 2018, 卷号: 18, 期号: 23, 页码: 3606-3616
Authors:  Wang, Yaqing;  Wang, Hui;  Deng, Pengwei;  Chen, Wenwen;  Guo, Yaqiong;  Tao, Tingting;  Qin, Jianhua
Favorite  |  View/Download:11/0  |  Submit date:2019/06/20
Short-chain chlorinated paraffins (SCCPs) induced thyroid disruption by enhancement of hepatic thyroid hormone influx and degradation in male Sprague Dawley rats 期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2018, 卷号: 625, 页码: 657-666
Authors:  Gong, Yufeng;  Zhang, Haijun;  Geng, Ningbo;  Xing, Liguo;  Fan, Jingfeng;  Luo, Yun;  Song, Xiaoyao;  Ren, Xiaoqian;  Wang, Feidi;  Chen, Jiping
Favorite  |  View/Download:16/0  |  Submit date:2019/06/20
Short-chain Chlorinated Paraffins  Thyroid Disruption  Hepatic Metabolism  Thyroid Hormone  Constitutive Androstane Receptor  
Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography-High-Resolution Mass Spectrometry 期刊论文
ANALYTICAL CHEMISTRY, 2018, 卷号: 90, 期号: 9, 页码: 5712-5718
Authors:  Yu, Di;  Zhou, Lina;  Xuan, Qiuhui;  Wang, Lichao;  Zhao, Xinjie;  Lu, Xin;  Xu, Guowang
Favorite  |  View/Download:12/0  |  Submit date:2019/06/20
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2 期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 77, 页码: 320-329
Authors:  Weng, Zi-Miao;  Ge, Guang-Bo;  Dou, Tong-Yi;  Wang, Ping;  Liu, Ping-Kun;  Tian, Xin-Hui;  Qiao, Nan;  Yu, Yang;  Zou, Li-Wei;  Zhou, Qi;  Zhang, Wei-Dong;  Hou, Jie
Favorite  |  View/Download:15/0  |  Submit date:2019/06/20
Flavonoids  Human Carboxylesterase 2 (Hce2)  Structure-inhibition Relationships  Selectivity  Inhibition Mechanism