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Recent progress and challenges in screening and characterization of UGT1A1 inhibitors 期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 258-278
Authors:  Lv, Xia;  Xia, Yangliu;  Finel, Moshe;  Wu, Jingjing;  Ge, Guangbo;  Yang, Ling
Favorite  |  View/Download:3/0  |  Submit date:2019/06/20
UGT1A1 inhibitors  Drug/herbdrug interactions  Probe substrates  High-throughput screening  
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu 期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
Authors:  Dai, Zi-Ru;  Ning, Jing;  Sun, Gui-Bo;  Wang, Ping;  Zhang, Feng;  Ma, Hong-Ping;  Zou, Li-Wei;  Hou, Jie;  Wu, Jing-Jing;  Ge, Guang-Bo;  Sun, Xiao-Bo;  Yang, Ling
Favorite  |  View/Download:8/0  |  Submit date:2019/06/20
bufotalin  cytochrome P450 3A (CYP3A)  hydroxylation  human liver microsomes (HLMs)  docking simulations  
New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9 期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 卷号: 122, 期号: 4, 页码: 424-428
Authors:  Xiao, Ling;  Zhu, Liangliang;  Li, Wenjuan;  Li, Conghu;  Cao, Yunfeng;  Ge, Guangbo;  Sun, Xiaoyu
Favorite  |  View/Download:4/0  |  Submit date:2019/06/20
Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases 期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2018, 卷号: 284, 页码: 48-55
Authors:  Lv, Xia;  Zhang, Jian-Bin;  Wang, Xin-Xin;  Hu, Wen-Zhong;  Shi, Yu-Sheng;  Liu, Shu-Wen;  Hao, Da-Cheng;  Zhang, Wei-Dong;  Ge, Guang-Bo;  Hou, Jie;  Yang, Ling
Favorite  |  View/Download:8/0  |  Submit date:2019/06/20
Amentoflavone  Udp-glucuronosyltransferases  Broad-spectrum Inhibitor  Herb-drug Interactions (Hdis)  
Study of a series of fluorophore-labeled artesunate derivatives Design, analysis and application 期刊论文
DYES AND PIGMENTS, 2017, 卷号: 146, 页码: 414-419
Authors:  Yang, Zihao;  Ge, Guangbo;  Liu, Fengyu;  Chen, Su-Shing;  Sun, Shiguo
Favorite  |  View/Download:16/0  |  Submit date:2017/12/19
Artesunate (Art)  Fluorophore  Covalent Modification  
Study of a series of fluorophore-labeled artesunate derivatives Design, analysis and application 期刊论文
DYES AND PIGMENTS, 2017, 卷号: 146, 页码: 414-419
Authors:  Yang, Zihao;  Ge, Guangbo;  Liu, Fengyu;  Chen, Su-Shing;  Sun, Shiguo
Favorite  |  View/Download:20/0  |  Submit date:2017/12/19
Artesunate (Art)  Fluorophore  Covalent Modification  
Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1 期刊论文
ACTA PHARMACEUTICA SINICA B, 2017, 卷号: 7, 期号: 6, 页码: 657-664
Authors:  Cheng, Xuewei;  Lv, Xia;  Qu, Hengyan;  Li, Dandan;  Hu, Mengmeng;  Guo, Wenzhi;  Ge, Guangbo;  Dong, Ruihua
Favorite  |  View/Download:3/0  |  Submit date:2019/06/20
Icotinib  Erlotinib  Ugt1a1  Inhibitory Effects  Drug-drug Interacts (Ddis)  
Comparative metabolism of DDAO benzoate in liver microsomes from various species 期刊论文
TOXICOLOGY IN VITRO, 2017, 卷号: 44, 页码: 280-286
Authors:  Ma, Hong-Ying;  Yang, Jia-Da;  Hou, Jie;  Zou, Li-Wei;  Jin, Qiang;  Hao, Da-Cheng;  Ning, Jing;  Ge, Guang-Bo;  Yang, Ling
Favorite  |  View/Download:45/0  |  Submit date:2017/12/19
Ddab Hydrolysis  Carboxylesterase 2 (Ce2)  Species Differences  Liver Microsomes  
Comparative metabolism of DDAO benzoate in liver microsomes from various species 期刊论文
TOXICOLOGY IN VITRO, 2017, 卷号: 44, 页码: 280-286
Authors:  Ma, Hong-Ying;  Yang, Jia-Da;  Hou, Jie;  Zou, Li-Wei;  Jin, Qiang;  Hao, Da-Cheng;  Ning, Jing;  Ge, Guang-Bo;  Yang, Ling
Favorite  |  View/Download:57/0  |  Submit date:2017/12/19
Ddab Hydrolysis  Carboxylesterase 2 (Ce2)  Species Differences  Liver Microsomes  
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis 期刊论文
FITOTERAPIA, 2017, 卷号: 119, 页码: 26-31
Authors:  Zhao, Jin;  Sun, Tao;  Wu, Jing-Jing;  Cao, Yun-Feng;  Fang, Zhong-Ze;  Sun, Hong-Zhi;  Zhu, Zhi-Tu;  Yang, Kun;  Liu, Yong-Zhe;  Gonzalez, Frank J.;  Yin, Jun
Favorite  |  View/Download:52/0  |  Submit date:2017/10/29
Gomisin c  Gomisin g  Cyp3a4  Cyp3a5  Inhibition  Herb-drug Interactions