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Recent progress and challenges in screening and characterization of UGT1A1 inhibitors 期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 258-278
Authors:  Lv, Xia;  Xia, Yangliu;  Finel, Moshe;  Wu, Jingjing;  Ge, Guangbo;  Yang, Ling
Favorite  |  View/Download:3/0  |  Submit date:2019/06/20
UGT1A1 inhibitors  Drug/herbdrug interactions  Probe substrates  High-throughput screening  
New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9 期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 卷号: 122, 期号: 4, 页码: 424-428
Authors:  Xiao, Ling;  Zhu, Liangliang;  Li, Wenjuan;  Li, Conghu;  Cao, Yunfeng;  Ge, Guangbo;  Sun, Xiaoyu
Favorite  |  View/Download:4/0  |  Submit date:2019/06/20
A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 23, 页码: 9664-9675
Authors:  Lv, Xia;  Feng, Lei;  Ai, Chun-Zhi;  Hou, Jie;  Wang, Ping;  Zou, Li-Wei;  Cheng, Jie;  Ge, Guang-Bo;  Cui, Jing-Nan;  Yang, Ling
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Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1 期刊论文
ACTA PHARMACEUTICA SINICA B, 2017, 卷号: 7, 期号: 6, 页码: 657-664
Authors:  Cheng, Xuewei;  Lv, Xia;  Qu, Hengyan;  Li, Dandan;  Hu, Mengmeng;  Guo, Wenzhi;  Ge, Guangbo;  Dong, Ruihua
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Icotinib  Erlotinib  Ugt1a1  Inhibitory Effects  Drug-drug Interacts (Ddis)  
UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated? 期刊论文
MOLECULAR PHARMACEUTICS, 2017, 卷号: 14, 期号: 9, 页码: 2875-2883
Authors:  Troberg, Johanna;  Jarvinen, Erkka;  Ge, Guang-Bo;  Yang, Ling;  Finel, Moshe
Favorite  |  View/Download:13/0  |  Submit date:2017/12/20
Udp-glucuronosyltransferase  Recombinant Ugt1a10  Intestine Microsomes  Intestinal Glucuronidation  Estradiol  Estrone  Morphine  Sn-38  Amc  Nchn  Bavachinin  
UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated? 期刊论文
MOLECULAR PHARMACEUTICS, 2017, 卷号: 14, 期号: 9, 页码: 2875-2883
Authors:  Troberg, Johanna;  Jarvinen, Erkka;  Ge, Guang-Bo;  Yang, Ling;  Finel, Moshe
Favorite  |  View/Download:24/0  |  Submit date:2017/12/20
Udp-glucuronosyltransferase  Recombinant Ugt1a10  Intestine Microsomes  Intestinal Glucuronidation  Estradiol  Estrone  Morphine  Sn-38  Amc  Nchn  Bavachinin  
Identification of human UDP-glucuronosyltransferase isoforms involved in the isofraxidin glucuronidation and assessment of the species differences of the reaction 期刊论文
FITOTERAPIA, 2017, 卷号: 117, 页码: 118-125
Authors:  Meng, Fanxing;  Li, Yan;  He, Guiyuan;  Ge, Guangbo;  Liu, Shumin
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Isofraxidin  Udp-glucuronosyltransferases (Ugts)  Human Liver Microsomes (Hlm)  Human Intestinal Microsomes (Him)  Species Differences  
Recent progress in the discovery of natural inhibitors against human carboxylesterases 期刊论文
FITOTERAPIA, 2017, 卷号: 117, 页码: 84-95
Authors:  Wang, Dan-Dan;  Zou, Li-Wei;  Jin, Qiang;  Hou, Jie;  Ge, Guang-Bo;  Yang, Ling
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Carboxylesterases  Hce1  Hce2  Natural Inhibitors  High-throughput Screening  
The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B 期刊论文
PHYTOTHERAPY RESEARCH, 2016, 卷号: 30, 期号: 11, 页码: 1872-1878
Authors:  Liu, Xin;  Chen, Da-Wei;  Wu, Xue;  Zhao, Zhenying;  Fu, Zhi-Wei;  Huang, Chun-Ting;  Ye, Li-Xin;  Du, Zuo;  Yu, Yang;  Fang, Zhong-Ze;  Sun, Hong-Zhi
Favorite  |  View/Download:48/0  |  Submit date:2017/10/29
Praeruptorin a  Praeruptorin b  Udp-glucuronosyltransferases (Ugts)  Drug-drug Interaction (Ddi)  
Strong Specific Inhibition of UDP-glucuronosyltransferase 2B7 by Atractylenolide I and III 期刊论文
PHYTOTHERAPY RESEARCH, 2016, 卷号: 30, 期号: 1, 页码: 25-30
Authors:  Zhang, Qian;  Cao, Yun-Feng;  Ran, Rui-Xue;  Li, Rong-Shan;  Wu, Xue;  Dong, Pei-Pei;  Zhang, Yan-Yan;  Hu, Cui-Min;  Wang, Wei-Ming
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Atractylenolide i  Atractylenolide Iii  Drug-drug Interaction