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Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites 期刊论文
XENOBIOTICA, 2017, 卷号: 47, 期号: 6, 页码: 498-504
Authors:  Liang, Si-Cheng;  Ge, Guang-Bo;  Xia, Yang-Liu;  Dong, Pei-Pei;  Wang, Ping;  Qi, Xiao-Yi;  Tu, Cai-Xia;  Yang, Ling
Favorite  |  View/Download:33/0  |  Submit date:2017/10/29
Daphnetin  Comt Inhibitor  8-o-methyldaphnetin  Ligand-protein Interaction  Phase Ii Metabolite  Structural Modification  
In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis 期刊论文
JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 卷号: 104, 期号: 10, 页码: 3557-3564
Authors:  Liang, Si-Cheng;  Ge, Guang-Bo;  Xia, Yang-Liu;  Zhang, Jiang-Wei;  Qi, Xiao-Yi;  Tu, Cai-Xia;  Yang, Ling
Favorite  |  View/Download:65/0  |  Submit date:2015/11/17
Daphnetin  Glucuronidation  Methyl Substitution  Structural Modification  Metabolic Stability  Phase Ii Enzymes  Glucuronosyltransferases  Human Liver Microsomes  Enzyme Kinetics  Metabolic Clearance  
Inhibitory effects of sanguinarine on human liver cytochrome P450 enzymes 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2013, 卷号: 56, 页码: 392-397
Authors:  Qi, Xiao-Yi;  Liang, Si-Cheng;  Ge, Guang-Bo;  Liu, Yong;  Dong, Pei-Pei;  Zhang, Jiang-Wei;  Wang, Ao-Xue;  Hou, Jie;  Zhu, Liang-Liang;  Yang, Ling;  Tu, Cai-Xia;  Yang L(杨凌);  Tu CX(涂彩霞)
Adobe PDF(725Kb)  |  Favorite  |  View/Download:227/85  |  Submit date:2014/09/11
Sanguinarine  Human Liver Microsomes  Cytochrome P450 Enzyme  Drug-drug Interaction  Time-dependent Inhibition  
C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2 期刊论文
XENOBIOTICA, 2011, 卷号: 41, 期号: 5, 页码: 349-357
Authors:  Wang, Ao-Xue;  Hu, Ying;  Liu, Hui-Xin;  Qi, Xiao-Yi;  Liu, Yong;  Tu, Cai-Xia;  Yang, Ling;  Hui-XinLiu
Adobe PDF(838Kb)  |  Favorite  |  View/Download:315/86  |  Submit date:2012/07/09
Liquiritigenin  Cytochrome P450  Human Liver Microsomes  Metabolism  
Rapid profiling and target analysis of principal components in Fuling Decoctions by UFLC-DAD-ESI-MS 期刊论文
FITOTERAPIA, 2010, 卷号: 81, 期号: 6, 页码: 662-667
Authors:  Wang, Ao-Xue;  Ge, Guang-Bo;  Qi, Xiao-Yi;  Hu, Ying;  Liang, Si-Cheng;  Yang, Ling;  Tu, Cai-Xia;  Tu CX
Favorite  |  View/Download:175/0  |  Submit date:2010/11/30
Uflc-dad-esi-ms  Fuling Decoction  Genipingentiobioside  Geniposide  Paeoniflorin  Liquiritin