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Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites 期刊论文
XENOBIOTICA, 2017, 卷号: 47, 期号: 6, 页码: 498-504
Authors:  Liang, Si-Cheng;  Ge, Guang-Bo;  Xia, Yang-Liu;  Dong, Pei-Pei;  Wang, Ping;  Qi, Xiao-Yi;  Tu, Cai-Xia;  Yang, Ling
Favorite  |  View/Download:31/0  |  Submit date:2017/10/29
Daphnetin  Comt Inhibitor  8-o-methyldaphnetin  Ligand-protein Interaction  Phase Ii Metabolite  Structural Modification  
Methylation, Glucuronidation, and Sulfonation of Daphnetin in Human Hepatic Preparations In Vitro: Metabolic Profiling, Pathway Comparison, and Bioactivity Analysis 期刊论文
JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 卷号: 105, 期号: 2, 页码: 808-816
Authors:  Liang, Si-Cheng;  Xia, Yang-Liu;  Hou, Jie;  Ge, Guang-Bo;  Zhang, Jiang-Wei;  He, Yu-Qi;  Wang, Jia-Yue;  Qi, Xiao-Yi;  Yang, Ling
Favorite  |  View/Download:1/0  |  Submit date:2019/06/20
Daphnetin  Methylation  Glucuronidation  Sulfonation  8-o-methyldaphnetin  Anti-inflammatory Activity  
Identifying and applying a highly selective probe to simultaneously determine the -glucuronidation activity of human UGT1A3 and UGT1A4 期刊论文
Scientific Reports, 2016, 卷号: 5, 期号: 0, 页码: 096271
Authors:  Li Jiang;  Liang SC(梁思成);  Chao Wang;  Ge GB(葛广波);  Xiao-Kui Huo;  Xiao-Yi Qi;  Sa Deng;  Ke-Xin Liu;  Xiao-Chi Ma
Favorite  |  View/Download:46/0  |  Submit date:2016/11/24
In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis 期刊论文
JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 卷号: 104, 期号: 10, 页码: 3557-3564
Authors:  Liang, Si-Cheng;  Ge, Guang-Bo;  Xia, Yang-Liu;  Zhang, Jiang-Wei;  Qi, Xiao-Yi;  Tu, Cai-Xia;  Yang, Ling
Favorite  |  View/Download:57/0  |  Submit date:2015/11/17
Daphnetin  Glucuronidation  Methyl Substitution  Structural Modification  Metabolic Stability  Phase Ii Enzymes  Glucuronosyltransferases  Human Liver Microsomes  Enzyme Kinetics  Metabolic Clearance  
Structural Modifications at the C-4 Position Strongly Affect the Glucuronidation of 6;7-Dihydroxycoumarins 期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 1, 页码: 553
Authors:  Xia YL(夏杨柳);  Ge GB(葛广波);  Wang P(王平);  Liang SC(梁思成);  He YQ(何芋歧);  Ning J(宁静);  Qian XK(钱星凯);  Li Y(李妍);  Yang L(杨凌)
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LiAlH4/碳包覆金属纳米粒子(Ni-Co@C)复合储氢材料及其制备方法 专利
专利类型: 发明, 专利号: CN201210181590.3, 申请日期: 2015-06-10, 公开日期: 2015-06-10
Inventors:  孙立贤;  焦成丽;  张箭;  徐芬;  司晓亮;  赵梓名
Favorite  |  View/Download:59/0  |  Submit date:2015/11/16
Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4 期刊论文
SCIENTIFIC REPORTS, 2015, 卷号: 5
Authors:  Jiang, Li;  Liang, Si-Cheng;  Wang, Chao;  Ge, Guang-Bo;  Huo, Xiao-Kui;  Qi, Xiao-Yi;  Deng, Sa;  Liu, Ke-Xin;  Ma, Xiao-Chi
Favorite  |  View/Download:45/0  |  Submit date:2015/11/17
Structural Modifications at the C-4 Position Strongly Affect the Glucuronidation of 6,7-Dihydroxycoumarins 期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 4, 页码: 553-560
Authors:  Xia, Yang-Liu;  Ge, Guang-Bo;  Wang, Ping;  Liang, Si-Cheng;  He, Yu-Qi;  Ning, Jing;  Qian, Xing-Kai;  Li, Yan;  Yang, Ling
Favorite  |  View/Download:63/0  |  Submit date:2015/11/17
Species-associated differences in the inhibition of propofol glucuronidation by magnolol. 期刊论文
Journal of the American Association for Laboratory Animal Science, 2014, 卷号: 53, 期号: 4, 页码: 408
Authors:  YangL;  ZhuL;  Ge GB(葛广波);  XiaoL;  WuY;  Liang SC(梁思成);  Cao YF(曹云峰);  Yang L(杨凌);  WangD
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Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin 期刊论文
DRUG METABOLISM AND PHARMACOKINETICS, 2014, 卷号: 29, 期号: 2, 页码: 135-140
Authors:  Xia, Yang-Liu;  Liang, Si-Cheng;  Zhu, Liang-Liang;  Ge, Guang-Bo;  He, Gui-Yuan;  Ning, Jing;  Lv, Xia;  Ma, Xiao-Chi;  Yang, Ling;  Yang, Sheng-Li;  Ge GB(葛广波)
Adobe PDF(1101Kb)  |  Favorite  |  View/Download:84/43  |  Submit date:2015/11/16
Fraxetin  Udp-glucuronosyltransferases (Ugts)  Ugt1a9  Glucuronidation  Human Liver Microsomes (Hlms)